Guava Leaf Extract Diminishes Hyperglycemia and Oxidative Stress, Prevents β-Cell Death, Inhibits Inflammation, and Regulates NF-kB Signaling Pathway in STZ Induced Diabetic Rats

Figure 3

(a) Effect of GLE on the liver histology of the control and experimental rats (A) and (B) shows normal histology of liver with central vein. (C) Liver histology of diabetic rats (group 3) shows congestion of sinusoidal dilatation (indicated by arrow ), inflammation of the central vein (indicated by arrow ⇢), and focal necrosis in the hepatocytes in diabetic control rats. (D) Liver histology of treatment group (group 4) shows reduced inflammation, a significant reduction in sinusoidal dilatation (indicated by arrow ⇢), and tissue architecture near to that of normal. (E) Liver histology of standard drug group (group 5) also shows reduced inflammation, a significant reduction in sinusoidal dilatation (indicated by arrow ⇢), and tissue architecture near to that of normal. (b) Effect of GLE on the kidney histology of the control and experimental rats (A) and (B) shows normal kidney histology of control (group 1) and GLE control (group 2). (C) Kidney histology of diabetic rats (group 3) showed multiple foci of hemorrhage, necrosis, and swelling of tubules (indicated by arrow ). (D) Kidney histology of treatment group (group 4) shows reduced necrosis and no swelling of tubules (indicated by arrow ⇢). (E) Kidney histology of standard drug group (group 5) also shows reduced necrosis and no swelling of tubules (indicated by arrow ⇢).

(a)

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