Research Article
Inhibitory Effects of Compounds and Extracts from Ampelopsis brevipedunculata on IL-6-Induced STAT3 Activation
Table 1
Inhibitory effects of the major compounds from Ampelopsis brevipedunculata on IL-6/STAT3 activation.
| | Compound | IC50 (μM) | Compound | IC50 (μM) |
| | Betulin (1) | 3.12 ± 0.31 | Ethyl gallate (10) | 44.13 ± 3.16 | | Betulinic acid (2) | 6.98 ± 0.34 | Ethyl gallyl 4-O-α-D-glucopyranoside (11) | 22.85 ± 0.74 | | β-Sitosterol (3) | > 50 | Syringic acid (12) | 15.82 ± 4.70 | | β-Sitosterol glucoside (4) | > 50 | Benzyl 6′-O-galloyl-β-D-glucopyranoside (13) | 4.99 ± 2.02 | | Aromadendrin (5) | 49.73 ± 10.15 | Ellagic acid (14) | 4.85 ± 1.73 | | 3-O-Glycoside-aromadendrin (6) | > 50 | 3′-O-Methylellagic acid 4-O-α-L-rhamnopyranoside (15) | > 50 | | Catechin (7) | > 50 | 4′-O-(β-D-Glucopyranosyl)-3,3′4-tri-O-methylellagic acid (16) | > 50 | | Gallic acid (8) | 27.30 ± 3.58 | Resveratrol (17) | 21.18 ± 1.10 | | Vanillic acid (9) | > 50 | | 13.60 ± 0.36 |
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Genistein was used as the positive control. |
