Characterization of Atherosclerosis Formation in a Murine Model of Type IIa Human Familial Hypercholesterolemia

Table 1

Lipid profiles of Wt, L, A, and L/A mice.

	L/A	L/A	Wt	L	A	L/A	L/A	L/A	L/A	L/A
Age (weeks)	12	18	24	24	24	24	36	48	60	72
N	14	16	17	14	11	45	38	26	13	17
Body weight (g)	26.3 ± 1.6	27.4 ± 2.1	28.7 ± 2.7	28.4 ± 2.4	31.7 ± 3.0	29.0 ± 2.4	29.3 ± 3.0	32.8 ± 3.2	34.5 ± 4.1	31.8 ± 2.3
Total-C (mg/dL)	341 ± 68	347 ± 66	66.6 ± 8.3	255.1 ± 45.5	74.6 ± 13.2	350 ± 79	337 ± 96	348 ± 64	335 ± 30	325 ± 77
VLDL-C (mg/dL)	22.8 ± 10.8	23.3 ± 5.5	NA	20.0 ± 7.4	NA	36.1 ± 10.3	21.4 ± 7.8	29.6 ± 11.3	21.1 ± 9.2	19.8 ± 9.8
LDL-C (mg/dL)	275 ± 60	268 ± 57	NA	163.2 ± 19.9	NA	264 ± 50	267 ± 84	274 ± 51	271 ± 23	271 ± 67
HDL-C (mg/dL)	44.1 ± 8.0	49.4 ± 9.1	NA	97.0 ± 26.1	NA	47.4 ± 16.1	43.8 ± 13.4	40.2 ± 12.2	36.2 ± 4.9	33.5 ± 11.6
LDL-C/HDL-C	6.4 ± 1.7	5.5 ± 0.7	NA	1.8 ± 0.6	NA	6.2 ± 2.6	6.3 ± 1.9	7.2 ± 1.7	7.3 ± 1.4	8.5 ± 2.0
Triglyceride (mg/dL)	168 ± 33	155 ± 22	63.4 ± 20.3	102.6 ± 28.8	75.4 ± 21.6	154 ± 28	153 ± 33	159 ± 25	157 ± 28	120 ± 22

Number of mice used at each age.
Total cholesterol.
Cholesterol contained in VLDL.
Cholesterol contained in LDL.
Cholesterol contained in HDL.