Characterization of Atherosclerosis Formation in a Murine Model of Type IIa Human Familial Hypercholesterolemia

Figure 2

The appearance of aortic arch of (a) Wt, (b) A (c) L, and (d) L/A mice at 24 weeks of age. There are no clear atherosclerotic plaques in Wt (a) and A mice (b) and even in L mice (c) at this time point on normal chow diet. On the other hand, apparent atherosclerotic plaques are visible in branching portions and the aortic arch in L/A mice (black arrowheads) (d).

(a)

(b)

(c)

(d)