| | | age | | | | | | | | background | sex | cisplatin | | | | | | GEM model | (breeder) | N | dose | end | mortality | S | measured parameters | Ref. |
| | | 25-30g | | | | | | | | 129/SV | male | 10 mg/kg | | | | BUN, Cr, Cr clearance, HO-1, p21mRNA | | CYP2e1−/− | (NIH) | N=10 | ip | D3 | nr | ↓ | and protein, TUNEL | [74] |
| Oct1−/− | | 8-12wk | | | | ns | | | Oct2−/− | FVB | male | 10 mg/kg | | | ns | | | Oct1/2/−/− | (Taconic) | N=11 | ip | D3 | nr | ↓ | Histology, Cr, BUN, ALT↑, ALP↓ | [35] |
| | | 6-10wk | | | | | | | | C57BL/6 | male, female | 15 mg/kg | | | | | | GstP1/P2−/− | (UK) | N=5-9 | ip | D5 | 0% | ↓ | Cr, ATN, WBC | [75] |
| | | 11-15wk | | | | | D3:BUN, Cr, AST | | Mate1−/− | | male | 15 mg/kg | | | | mortality | | (pyrimethamine) | C57BL/6 | N=6 | ip | D6 | 100% | ↑ | | [41] |
| Mdk−/− | 129SV | 8-12wk | 12 mg/kg | D7 | nr | ↓ | ↓BUN, TUNEL, histology, ≈leukocytes | [76] | | | male | ip | | | | infiltration (neutrophil, macrophages, Tcells), | | | | N=6 | | | | | Bcl-2, KC protein, MCP-1, MIP-2 | |
| | | 8-10wk | | | | | Survival, histology, BUN, Cr, leukocyte | | | | male | 15 mg/kg | | | | infiltration, TUNEL, TNFα, ICAM1 mRNA, | | PI3Kγ−/− | C57BL/6 | N=25 | ip | D5 | 44% | ↑ | proteins, p-Akt, p-Bad | [77] |
| | | 10-12wk | | | | | | | | B6x129/SF2/J | male | 20 mg/kg | | | | | | E2F1−/− | (Jax) | N=6 | ip | D3 | nr | ↓ | ↓BUN, Cr, histology, | [78] |
| p53−/− | nr | N=6 | 20 mg/kg | | | | | | (pifithrin-α) | (Jax) | ip | D3 | nr | ↓ | ↓BUN, Cr, histology | [79] |
| p53−/− | C57BL/6J | 8-10 wk, male | 30 mg/kg | | | | | | (pifithrin-α) | (Jax) | N=22-29 | ip | D3 | nr | ↓ | ↓BUN, Cr, histology | [80] |
| | C57BL/6 | 8-10wk, male | 30 mg/kg | | | | | | Bax−/− | (Jax) | N=3-8 | ip | D3 | nr | ↓ | BUN, Cr, ATN, TUNEL, cytochrome C | [81] |
| | | | | | | | Histology, BUN, Cr, neutrophils infiltration, | | | C57BL/6 | 8-10wk, male | | | | | TUNEL, Casp-1,-3,-8,-9 activity, IL-1β | | Casp-1−/− | (Japan) | N=4-15 | 30 mg/kg | D3 | nr | ↓ | | [82] |
| | | 8-15 wk, male | | | | | BUN, histology, TUNEL | | p21-/- | nr | N=5-6 | 20 mg/kg | D3 | 30% | ↑ | | [83] |
| HO-1+/- | | 12-16wk | 20 mg/kg | | | ≈ | | | HO-1−/− | nr | N=8 | ip | D3 | | ↑ | ↓BW, ↑BUN | [84] |
| | C57BL/10Sn | 6-8 wk | | D3 | | | | | C5−/− | (Jax) | male | | | ↓ | BUN, Cr, histology, MDA, MPO, | [85] | | BALB/c | N=5-12 | 20 mg/kg | | | nitrotyrosine, TNF-α, IL-1β, ICAM-1, casp-3,8,9, STAT3, NF-κB | C5aR−/− | (Jax) | SPF | ip | | ↓ | |
| | DBA/1lacJ x | 3-4 months | | | | | BW, histology, BUN, Cr, Hct, | | mPGES-1−/− | C57BL/6 x | male | 20 mg/kg | | | | TNFα, IL-1β; | | (celecoxib) | 129/SV | N=6-16 | ip | D3 | nr | ↓ | | [86] |
| TNFα -/- | | 8-9 wk | | | | | Histology, BUN, leukocyte infiltration | | (GM6001, | B6129SF2/J | male | | | | | | | Pentoxifylline | (Jax) | N=7 | 20 mg/kg | D3 | nr | ↓ | | [87] |
| | C57BL/6 | 8-10wk, male | | | | | Histology, BUN, Cr, neutrophil infiltration, | | TLR4−/− | (Jax) | N=4-7 | 20 mg/kg | D3 | nr | ↓ | cytokines | [88] |
| | | | | D1 | | | Kidney: ↑neutrophils, CXCL1, CXCL2, | | | | 8-10wk | | | | | ≈CD4+, ↓CD4+CD25+, Foxp3 | | N=6-10 | TLR9−/− | C57BL/6 | | 20 mg/kg | D3 | nr | ↑ | Blood: ↑BUN; Kidney: ↑histology score | [72] |
| | C57BL/6 | 8-10 wks | 15mg/kg | | | | Blood: ≈BUN; Kidney: ≈histology score | | Tcrd−/− | (Jax) | ♂, N=9 | ip | D4 | nr | ns | | [67] |
| Asc−/− | C57BL/6 | 8-10 wk, male | 15mg/kg | | | | Blood: ↓BUN; | | TLR2−/− | (Jax) | N=5 | ip | D4 | nr | ↓ | Kidney: ↓histology score, IL-17A, IL-1β | [67] |
| | C57BL/6 | 8-10 wk, male | 15mg/kg | | | | Blood: ↓BUN; Kidney: ↓histology score | | Rorγt-/- | (Jax) | N=9 | ip | D4 | nr | ↓ | | [67] |
| | | 8-10 wk, | | D1 | | | Kidney:↓neutrophils, ≈CD4+ T cells, CXCL1, | | IL-17A−/− | C57BL/6 | male | 15mg/kg | | | | CXCL2, CCL2, CCL5 | | (anti-IL-17A) | (Jax) | N=8 | ip | D4 | nr | ↓ | Blood: ↓BUN; Kidney: ↓histology score | [67] |
| | C57BL/6 | 8-10 wk, male | | | | | Histology, BUN, Cr, | | IL-6 −/− | (Jax) | N=4-6 | 30 mg/kg | D3 | nr | ns | | [65] |
| | | 10-12wk, | | | | | ↓Mortality, | | | C57BL/6J | male | | | | | ↑BUN | [89, 90] | IL-6−/− | (Jax) | N=9-18 | 30 mg/kg | D8 | 47% | ↓ | |
| | | 6-8 wk | | | | | Morality, Cr, histology, MPO, | | nu/nu B6.Cg-Foxn | C57BL/6 | male | | | | | TNFα, IFN-γ,IL-1β, KC | | (T-cell transfer) | (Jax) | N=3-14 | 40 mg/kg | D3 | 0% | ↓ | | [69] |
| | | 6-8wk | | D2 | 6% | | Mortality, BUN, Cr, histology, macrophage | | nu/nu (CD4+CD25+Treg | BALB/c | male | | D3 | 31% | | infiltration (F4/80 positive cells), TNFα, IL-1β | | transfer) | (South Korea) | N=16 | 40 mg/kg | D4 | 13% | ↓ | | [70] |
| CD4−/− | B6129S2 | 6-8 wk, male | | | | | ↓Morality, Cr, histology | | B6.129S2-Cd4tm1Mak | (Jax) | N=16 | 40 mg/kg | D3 | 38% | ↓ | | [69] |
| | | 8-10wk | | | | | Blood: ↓Cr; Kidney: ↓histology score | | CD4−/− CD4 tm1Mak | C57BL/6 | male | | | | | | | GK1.5 monoclonal AB | (Jax) | N= | 25 mg/kg | D3 | nr | ↓ | | [51] |
| | | 8-10wk | 10 mg/kg | | | | Blood: ≈BUN, Cr; Kidney: ≈caspase-3, | | CD4−/− CD4 tm1Mak | C57BL/6 | male | per week | | | | TUNEL,≈ IL-1, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, CXCL1, TNFα, IFN-γ | | GK1.5 monoclonal AB | (Jax) | N=10 | for 4 wks | 4wks | nr | ns | [91] |
| CD8−/− | B6129S2 | 6-8 wk, male | | | | | Mortality, Cr, histology | | B6.129S2-Cd8atm1Mak | (Jax) | N=16 | 40 mg/kg | D3 | 56% | ↓ | | [69] |
| | C57BL/6 | 8-10wk, male | | | | | Blood: ↓Cr; Kidney:↓histology score, | | CXCR2−/− | (Jax) | N=4 | 25 mg/kg | D3 | nr | ↓ | apoptosis | [51] |
| | C57BL/6 (wt) | 8-10wks | 12 mg/kg | | | | Blood: ↓BUN, serum TNF; Kidney: | | | (Jax) | N=7 | ip | D4 | 0% | ↓ | ↓histology score | [71] |
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