BioMed Research International

Research Article

Bone Marrow Metastasis Is an Early Stage of Bone Metastasis in Breast Cancer Detected Clinically by F18-FDG-PET/CT Imaging

Table 1

Structural and functional features of metastatic bone disease in 35 breast cancer patients as noted on F18-FDG-PET/CT scans both at baseline (pretreatment) for all patients and at follow-up (posttreatment) for 26 patients.


No	Age (y)	Interval (y)	Baseline F18-FDG PET/CT scan		Interval (mo)	Follow-up F18-FDG PET/CT scan
No	Age (y)	Interval (y)	BM lesions (PET)	Bone lesions (PET/CT)	Interval (mo)	BM lesions (PET)	Bone lesions (PET/CT)	Posttreatment response

1	80	0	14	44/44	—	—	—	—
2	38	0	6	16/16	3	0	0/19	Responsive
3	42	0	16	90/90	—	—	—	—
4	54	0	8	28/28	6	0	0/34	Responsive
5	42	0	24	110/110	4	0	0/130	Responsive
6	61	0	0	40/48	7	0	0/48	Responsive
7	42	0	0	35/43	6	0	0/43	Responsive
8	40	0	0	15/15	6	0	0/15	Responsive
9	54	0	0	40/40	4	0	40/40	Stable
10	40	0	0	9/9	7	0	0/9	Responsive
11	38	0	0	23/27	4	9	40/45	Progressive
12	55	0	0	12/12	10	0	0/12	Responsive
13	50	0	15	40/40	5	0	0/50	Responsive
14	55	0	0	88/88	5	0	0/88	Responsive
15	60	0	0	101/101	3	0	0/101	Responsive
16	60	0	0	79/79	6	0	79/79	Stable
17	45	0	0	65/65	6	0	0/65	Responsive
18	42	0	8	40/40	3	5	45/45	Stable
19	56	0	0	0/17	10	0	10/63	Progressive
20	32	0	0	3/3	6	0	0/3	Responsive
21	60	5	22	76/76	—	—	—	—
22	61	2	70	0/0	—	—	—	—
23	56	6	65	67/67	—	—	—	—
24	55	4	28	35/35	—	—	—	—
25	27	3	45	26/26	—	—	—	—
26	43	2	68	45/52	—	—	—	—
27	47	1	17	10/12	—	—	—	—
28	45	2	3	6/6	6	0	0/7	Responsive
29	40	3	0	0/1	6	0	0/1	Responsive
30	39	0.5	2	25/25	6	19	47/47	Progressive
31	45	7	3	4/6	7	0	0/8	Responsive
32	55	6	6	23/23	6	2	56/56	Progressive
33	54	0.5	0	0/13	9	14	60/81	Progressive
34	48	2	0	8/8	3	0	0/8	Responsive
35	48	3	0	88/88	3	0	0/88	Responsive

Total			420	1353		49	1185

BM = bone marrow metastatic lesions, = interval between tissue diagnosis of breast cancer and diagnosis of bone/bone marrow metastasis by F18-FDG-PET/CT scan, = interval between baseline and follow-up F18-FDG-PET/CT scans, ǂ = PET positive/CT occult lesions (BM lesions), and ¥ = PET positive/CT positive lesions (i.e., number of bone lesions seen on CT that are hypermetabolic on PET). Example: patient # 2 had 6 BM lesions (PET +ve/CT −ve) and 16 active bone lesions (PET +ve/CT +ve) on baseline. On follow-up, she had 19 inactive bone lesions (PET −ve/CT +ve) and all BM lesions had disappeared (3 lesions had become bone metastasis and 3 had resolved without causing bone destruction). F18-FDG PET/CT = fluorine-18 fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography.