Decreased Expression of Semaphorin3A/Neuropilin-1 Signaling Axis in Apical Periodontitis

Figure 1

Rat periapical lesion size at different stages. (a) 3D reconstruction of a rat periapical lesion presented in sagittal, horizontal, and coronal sections after micro-CT scanning. The zone in red indicates the volume of the periapical lesion from day 0 to day 35. (b) HE staining of rat periapical lesions at different stages. Histological lesions in the sagittal section are presented under ×25 magnification, scale bar = 15 mm. (c) TRAP staining of rat periapical lesions at different stages. Osteoclasts were identified as TRAP-positive cells with multinucleated cells (arrows) under ×400 magnification, scale bar = 5 μm. (d) RANKL-positive cells were stained dark brown (arrows) under ×400 magnification, scale bar = 5 μm. B: bone; A: apex.

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