Macrovascular Complications in Patients with Diabetes and Prediabetes

Table 1

Intensive glycemic control and cardiovascular events in type II diabetes. There was comparable CVD risk in the intensive glycemic control group and the standard therapy group. However, the risk of hypoglycemia is significantly higher in the groups with intensive control therapy.

Clinical trial	ACCORD		ADVANCE		VADT
Sample size	10,251		11,140		1,791
Median follow-up	3.5 years		5 years		5.6 years
Treatment group	Intensive control	Standard therapy	Intensive control	Standard therapy	Intensive control	Standard therapy
Mean HbA1c	6.7%	7.5%	6.5%	7.3%	6.9%	8.4%
CVD event	6.9%	7.2%	10.0%	10.6%	30.0%	34.0%
	()		()		()
CVD mortality	2.6%	1.8%	4.5%	5.2%	4.5%	3.7%
	()		()		()
All-cause mortality	5.0%	4.0%	8.9%	9.6%	11.4%	10.6%
	()		()		()
Hypoglycemia	10.5%	3.5%	2.7%	1.5%	1333 episodes	383 episodes
	()		()		()