Monoclonal Antibodies Radiolabeling with Rhenium-188 for Radioimmunotherapy

Figure 2

Schematic representation of indirect radiolabeling of antibodies with generator eluted using the prelabeling approach. An activated N₃S-chelator is first labeled with rhenium-188 by traschelation of a first produced []Re-citrate intermediate complex and then the resulting compound is conjugated to the antibody [32–34].