Aprepitant for the Treatment of Chronic Refractory Pruritus

Table 3

Drugs that may interact with aprepitant if used concurrently, based on CYP3A4 interactions.

CYP3A4 interaction	CYP3A4 substrates	CYP3A4 inducers	CYP3A4 inhibitors
Risk	Risk of increased or decreased plasma levels with concurrent aprepitant use	Risk of decreased aprepitant plasma levels	Risk of increased aprepitant plasma levels
Drugs	Pimozide	Rifampin	Ketoconazole
	Erlotinib		Diltiazem
	Warfarin
	Hormonal contraceptives
	Ifosfamide
	Methylprednisolone
	Dexamethasone