Review Article
Aprepitant for the Treatment of Chronic Refractory Pruritus
Table 3
Drugs that may interact with aprepitant if used concurrently, based on CYP3A4 interactions.
| CYP3A4 interaction | CYP3A4 substrates | CYP3A4 inducers | CYP3A4 inhibitors |
| Risk | Risk of increased or decreased plasma levels with concurrent aprepitant use | Risk of decreased aprepitant plasma levels | Risk of increased aprepitant plasma levels |
| Drugs | Pimozide | Rifampin | Ketoconazole | Erlotinib | ā | Diltiazem | Warfarin | ā | Hormonal contraceptives | Ifosfamide | Methylprednisolone | Dexamethasone |
|
|