Aprepitant for the Treatment of Chronic Refractory Pruritus

Table 2

Aprepitant side effects reported in ≥3% of patients by organ system for adults and pediatric patients [5, 14, 19].

Adult population
Neurologic	Fatigue, vertigo, drowsiness, headache
Gastrointestinal and hepatic	Diarrhea, constipation, dyspepsia, abdominal pain, increased alanine aminotransferase, nausea
Neuromuscular and musculoskeletal	Asthenia, hiccups
Hematologic	Decreased WBC count
Endocrine and metabolic	Dehydration
Cardiovascular	Hypotension
Pediatric population
Neurologic	Headache, fatigue, dizziness
Gastrointestinal	Diarrhea, decreased appetite
Neuromuscular and musculoskeletal	Cough, hiccups
Hematologic	Neutropenia, decreased hemoglobin