Review Article

Aprepitant for the Treatment of Chronic Refractory Pruritus

Table 1

Aprepitant dosing by pruritus-associated disease based on prior studies.

Sézary syndrome80 mg daily for 10–15 days and then 80 mg on alternate days for 1.5–23 weeks [4, 10, 16]
OR
125 mg/80 mg/80 mg for 3 days, in 2-week repetitions for 6–24 weeks [9]

Mycosis fungoides80 mg daily for 4 months or longer for prophylaxis [12]
OR
125 mg/80 mg/80 mg for 3 days, in 2-week repetitions for 6–24 weeks [9, 14]

Cutaneous anaplastic large cell lymphoma125 mg/80 mg/80 mg for 3 days [18]

Lung adenocarcinoma80 mg daily continuously for prophylaxis [8]
OR
125 mg/80 mg/80 mg for 3 days, then alternating days of 125 mg and 80 mg for 2 months or longer for prophylaxis [11]

Breast carcinomaDay 1: 125 mg, day 3: 80 mg, day 5: 80 mg [7]

Metastatic solid tumorsDay 1: 125 mg, day 3: 80 mg, day 5: 80 mg [11]

Soft tissue sarcomaDay 1: 125 mg, day 3: 80 mg, day 5: 80 mg [7]

Hodgkin’s lymphoma80 mg daily for 2 weeks [15]

Chronic kidney disease80 mg daily for 3–13 days [5]

Hyperuricemia80 mg daily for 3–13 days [5]

Iron deficiency80 mg daily for 3–13 days [5]

Pruritus of unclear origin125 mg on day 1, 80 mg on days 2–4 [17]

Brachioradial pruritus80 mg daily for 7 days; repeat if relapse [13]