Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials

Table 3

Results of dose subgroup.

Factor	Zinc dose	Number of studies	Heterogeneity test			Weighted mean difference
					value	WMD	[95% CI]	value
Serum zinc (ug/dL)	<45 mg			27.52%			,	<0.001
	45–50 mg			95.90%	<0.001		,	0.014
	>50 mg			88.90%	<0.001		,	<0.001
BMI (kg/m2)	16.5 mg		-	-	-		,
	≥90 mg			13.70%			,
nPNA (g/kg/d)	11 mg		-	-	-		,	<0.001
	45 mg			23.00%			,
Dietary protein intake (g/kg/d)	45 mg			0.00%			,
	50 mg			0.00%			,
Albumin (g/dL)	<50 mg			85.60%			,
	≥50 mg			57.40%			,
Hemoglobin (g/dL)	<45 mg			71.87%			,
	≥45 mg			0.00%			,
HDL (mg/dL)	<50 mg			96.80%	<0.001		,
	≥50 mg			96.80%	<0.001		,
LDL (mg/dL)	<50 mg			79.40%			,
	≥50 mg			0.00%			,	<0.001
TC (mg/dL)	≤50 mg			0.00%			,	<0.001
	>50 mg			44.70%			,
TG (mg/dL)	<50 mg			87.00%			,
	≥50 mg		-	-	-		,
CRP (ng/mL)	11 mg		-	-	-		,	<0.001
	45 mg			52.60%			,	0.039
MDA (nmol/mL)	<50 mg			90.30%			,	0.017
	≥50 mg		-	-	-		,	<0.001

Note. -: values could not be calculated due to an insufficient number of studies; , and WMD was considered statistically significant.