Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials

Table 2

Summary of the effects of zinc supplementation in MHD patients.

Factor	Number of studies	Heterogeneity test			Weighted mean difference			Publication bias
				value	WMD	[95% CI]	value	Begg test	Egger test
Serum zinc (ug/dL)			90.7%	<0.001		[26.264, 30.713]	<0.001
BMI (kg/m2)			0%			[−0.762, 1.059]
nPNA (g/kg/d)			91.20%			[−0.161, 0.431]
Dietary protein intake (g/kg/d)			0%			[1.592, 14.408]	<0.001	-	-
Albumin (g/dL)			69.20%			[−0.016, 0.732]
Hemoglobin (g/dL)			81.6%			[−0.011, 1.522]
HDL (mg/dL)			91.90%	<0.001		[−3.142, 11.238]
LDL (mg/dL)			91.80%	<0.001		[−15.478, 57.534]
TC (mg/dL)			86.90%	<0.001		[−9.975, 42.371]
TG (mg/dL)			75.60%			[−34.711, 35.125]
CRP (ng/mL)			85.60%			[−15.579, −1.656]	0.015
MDA (nmol/mL)			87.70%	<0.001		[−1.945, −0.605]	<0.001
SOD (U/g Hb)			70.80%	0.064		[152.158, 562.978]	0.001	-	-

Note. -: values could not be calculated due to an insufficient number of studies; , and WMD was considered statistically significant.