Concordance of Hypermethylated DNA and the Tumor Markers CA 15-3, CEA, and TPA in Serum during Monitoring of Patients with Advanced Breast Cancer

Figure 1

Monitoring Patient A with advanced breast cancer by measuring serial concentrations of CA 15-3, CEA, TPA, and hypermethylated RASSF1A. ■ denotes the respective protein biomarkers CA 15-3, CEA, and TPA. △ denotes the hypermethylated RAS association (RalGDS/AF-6) domain family member 1A gene (RASSF1A). The clinical response changed from a partial response (PR) to progressive disease (PD) during chemotherapy. Sixteen serial serum samples were investigated. The marker response was partial response (PR), partial response continued (PRC), no change high (NCH), and progressive disease (PD) for CA 15-3, CEA, and TPA according to previously reported assessment criteria [4].