Heavy weight monofilament with small pore size (HWM) and low weight with large pore size multifilament (LWM) on the posterior abdominal wall of rats for 7, 14, 21, and 90 days.
(i) HWM: intense inflammation, embedded in connective tissue. (ii) LWM: less pronounced inflammatory response and fibrotic capsule, with collagen distributed within the mesh.
Implantation of Surgipro and cadaveric fascia lata in rabbit’s bladder neck for 6 and 12 weeks.
(i) Cadaveric fascia lata group: the implant was incorporated in a plate of fibrous tissue. (ii) Polypropylene mesh: inflammation localized on the graft.
Vicryl, Vypro, Prolene, Prolene Soft, and Mersuture were implanted in pigs peritoneum for 10 weeks.
(i) Vicryl: low level of inflammation and completely absorbed. (ii) Vypro: intense inflammation and strong fibrotic response. (iii) Prolene and Prolene Soft: well integrated, weak inflammatory response. (iv) Mersuture: no good integration.
24 grafts were explanted in women undergoing sling revision after 2–34 months. Grafts were polypropylene meshes, autologous fascia, porcine dermis, and cadaveric dermis.
No evidence of degradation or encapsulation, abundant host infiltration. Neovascularisation was visible.
Gynemesh in two sizes ( mm and mm) implanted in 20 adult ewes for 60 and 90 days, both on the abdominal and vaginal walls.
Implants were contracting more when implanted on the vaginal wall, compared to abdominal wall. Grafts implanted on the vaginal wall are stiffer than the ones implanted on the abdominal wall, after retrieval.
(i) 30% of the meshes caused vaginal erosion and exposure. (ii) 60% of the meshes had reduced surface (i.e., contracting after 90 days.)