BioMed Research International

Review Article

Transcriptome and Molecular Endocrinology Aspects of Epicardial Adipose Tissue in Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Observational Studies

Table 3

Top ten enriched KEGG pathway of DEGs in EAT samples from patients with and without cardiovascular diseases.
GO id  Functional description KEGG IDGenes in test setNumber of genes valueFDR  
value
4066HIF-1 signaling pathway SERPINE1, HMOX1, IL-6, FLT1, CYBB, EDN1, NOS371.56 × 10−91.82 × 10−7
4668TNF signaling pathway MAP3K8, IL-18R1, TNF-α, IL-6, ICAM1, CCL2, EDN171.91 × 10−91.82 × 10−7
4060Cytokine-cytokine receptor interactionIL-18RAP, IL-10, IL-6, CCR2, IL-18R1, TNF-α, FLT1, CCL284.97 × 10−83.56 × 10−6
4068FoxO signaling pathwayIL-10, SIRT1, IL-6, PRKAA2, SOD2, SLC2A461.59 × 10−78.1 × 10−6
5321Inflammatory bowel disease (IBD)IL-18RAP, IL-10, IL-18R1, TNF-α, IL-651.69 × 10−78.1 × 10−6
4920Adipocytokine signaling pathwayACSL1, SLC2A4, ADIPOQ, TNF-α, PRKAA252.51 × 10−71.03 × 10−5
5143African trypanosomiasisIL-6, IL-10, ICAM1, TNF-α46.01 × 10−72.16 × 10−5
5323Rheumatoid arthritisTNF-α, IL-6, ICAM1, FLT1, CCL258.29 × 10−72.64 × 10−5
5142Chagas disease
(American trypanosomiasis)		IL-10, SERPINE1, TNF-α, IL-6, CCL251.52 × 10−64.36 × 10−5
5140LeishmaniasisIL-10, NCF2, TNF-α, NCF141.2 × 10−52.94 × 10−4