Research Article
How to Choose In Vitro Systems to Predict In Vivo Drug Clearance: A System Pharmacology Perspective
| Drug | Expression systems | In vivo clearance (L/h) | References |
| Caffeine | Baculovirus | 5.88 | Obach et al. (2008) [32] | Melatonin | Baculovirus | 57.96 |
Mallo et al. (1990) [33] | Tacrine | Yeast | 235.2 | Obach et al. (2008) [32] | Theophylline (1,3-DMX) | E. coli and lymphoblastoid | 3.612 | Obach et al. (2008) [32] | Bupropion | Baculovirus | 5.415 |
Lei et al. (2010) [34], Hill et al. (2007) [35] | Efavirenz | Baculovirus | 5.483 |
Gengiah et al. (2012) [36], Chiappetta et al. (2010) [37] | Repaglinide | Baculovirus | 32.76 | Obach et al. (2008) [32] | Paclitaxel | Baculovirus | 26.88 | Obach et al. (2008) [32] | (R)-Warfarin | Baculovirus, E. coli, and lymphoblastoid | 0.231 | Obach et al. (2008) [32] | Phenytoin | Baculovirus and lymphoblastoid | 3.906 |
Hayes et al. (1975) [38] | Celecoxib | Lymphoblastoid and yeast | 21.05 |
Drug Bank [39], Paulson et al. (2001) [40] | Clobazam | Baculovirus | 2.49 | Drug Bank [39] | (R)-Lansoprazole (dexlansoprazole) | Baculovirus | 18.48 | Obach et al. (2008) [32] | (R)-Omeprazole | Baculovirus and lymphoblastoid | 35.28 | Obach et al. (2008) [32] | Atomoxetine | Baculovirus | 15.435 | Drug Bank [39] | Dextromethorphan | Baculovirus, E. coli, yeast, and lymphoblastoid | 40.59 |
Moghadamnia et al. (2003) [41], Kukanich and Papich (2004) [42] | Metoprolol | Lymphoblastoid | 54.6 | Obach et al. (2008) [32] | Perphenazine | Baculovirus | 113.4 | Obach et al. (2008) [32] | Tolterodine | Baculovirus | 10.5 |
Brynne et al. (1997) [43] | Venlafaxine | Lymphoblastoid and yeast | 40.95 | Drug Bank [39] | Alfentanil | Baculovirus | 16.38 | Obach et al. (2008) [32] | Astemizole | Yeast | 82.6 |
Lefebvre et al. (1997) [44] | Cisapride | Baculovirus | 14.20 |
Lowry et al. (2003) [45] | Cyclosporine | Baculovirus | 31.5 | Obach et al. (2008) [32] | Felodipine | Baculovirus and lymphoblastoid | 46.2 | Obach et al. (2008) [32] | Indinavir | Baculovirus | 75.6 | Obach et al. (2008) [32] | Maraviroc | Baculovirus | 44 |
Abel et al (2008) [46] | Midazolam | Baculovirus, E. coli, and lymphoblastoid | 22.26 | Obach et al. (2008) [32] | Pimozide | Baculovirus | 0.042 |
Desta et al. (1999) [47] | Quinidine | Lymphoblastoid | 16.8 | Obach et al. (2008) [32] | Sildenafil | Baculovirus | 38.22 | Obach et al. (2008) [32] | Sirolimus | Baculovirus | 2.73 |
Brattstram et al. (2000) [48] | Tacrolimus | Baculovirus | 4.63 | Obach et al. (2008) [32] | Triazolam | Baculovirus and lymphoblastoid | 12.6 | Obach et al. (2008) [32] | Vardenafil | Baculovirus | 54.6 | Obach et al. (2008) [32] |
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