Review Article
Zebrafish as a Model for the Study of Human Myeloid Malignancies
Table 2
The advantages and weaknesses in the xenograft model of zebrafish and mouse.
| ā | Item | Zebrafish | Mouse |
| Strengths | Maintenance cost | Low | Available | Maintenance space | Small | Large | Offspring | Large number | Less number | Immune system | Lack in early zebrafish embryos | Innate and adaption | Observation | Visualization (transparency and transgenic lines) | Limitation | Readout time | Hours to days | Days to months | Cell numbers required for xenotransplantation per animal | Less | Large | High-throughput drug screening | Available | Limitation |
| Weaknesses | Size of organs/vessels | Small | Large | Body temperature | Low | High | Lack of organs | Breast, lung, etc. | ā | Zebrafish antibodies | Limitation | More | Adult immune-permissive lines | Unavailable | Available |
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