N-3 Polyunsaturated Fatty Acids and Inflammation in Obesity: Local Effect and Systemic Benefit

Figure 2

Mitigation of AT local inflammation by n-3 PUFA as a result from normalization of AT storage and secretory function. In the presence of n-3 PUFA, it is clear that the population of small adipocytes increases, possibly with unchanged total fat mass due to reduced large adipocyte. Alteration in cellularity also includes reduced ATM content, along with transformation from M1 to M2 polarization state. The last confirmed observation is dramatically modified adipokine secretion.