Long-Term In Vitro Degradation of a High-Strength Brushite Cement in Water, PBS, and Serum Solution

Table 1

Summary of in vitro degradation rates, in terms of average mass loss per week, of brushite cements found in the literature. A range in degradation rate is given when several groups were studied, for example, variations in cement composition or variations in amount of liquid. Only data from degradation experiments performed at 37°C was included.

L/P ratio	Liquid	Time	Degradation rate; mass percentage points/week	Reference
0.22 mL/g	H2O	25 weeks	0.37	Present study
1.33 mL/g	H2O	16 days	7.1–8.9	[10]
0.22 mL/g	PBS	25 weeks	0.35	Present study
0.57 mL/g	PBS	90 days	1.5	[6]
0.5 mL/g	PBS	90 days	1.2–1.9	[19]
0.57 mL/g	PBS	28 days	2.1–4.8	[5]
0.8 mL/g	Ringers solution	28 days	2.8	[7]
0.5 mL/g	PBS	21 days	1.8	[15]
1 g/g	PBS	14 days	2.9–11.7	[14]
1 g/g	PBS	14 days	0.5–8.7	[8]
0.22 mL/g	Serum	25 weeks	0.22	Present study
0.57 mL/g	FBS	28 days	16.0	[5]
0.57 mL/g	FBS	90 days	4.4	[6]