Extraintestinal Helminth Infection Limits Pathology and Proinflammatory Cytokine Expression during DSS-Induced Ulcerative Colitis: A Role for Alternatively Activated Macrophages and Prostaglandins

Figure 9

The anticolitic effect of T. crassiceps is abrogated by indomethacin treatment. (a) Percentage of weight loss. (b) Disease index. (c) Photograph of gross pathology of colons from different groups of mice. (d) Length of colon in infected and uninfected mice with ulcerative colitis treated or not with indomethacin (3 mg/kg). (e) Histology of colons, left panel colon tissue microphotography (10x) stained with H&E, all other panels are tissue colon stained with Alcian blue to detect goblet cells (20x and 40x, resp.). (f) Number of goblet cells for all the groups. , , mice per group. Similar results were observed in two independent experiments.

(a)

(b)

(c)

(d)

(e)

(f)