Systematic Review of the Use of Phytochemicals for Management of Pain in Cancer Therapy

Table 2

Overview of the 7 full-text articles and associated phytochemicals included in this systematic review.

Study		Study design	Study duration	Phytochemical	Delivery	Patients	Country	Major study design bias
Bao et al. [21]	124	RCT, open label	Immediate intervention	Xiaozheng Zhitong Paste	Ointment	Multiple cancers with metastases	China	Control is not a placebo
Belcaro et al. [22]	80	RCT, open label	60 days	Meriva (lecithin delivery system of curcumin)	Oral	Chemo/radiotherapy postsurgical and multiple cancers	Italy	Heterogeneous cancer study population
Brooker et al. [23]	66	RCT, blinded	12 months	IH636 grape seed proanthocyanidin extract	Oral	Pain after high-dose radiotherapy for early breast cancer	UK	None
Costa Fortes et al. [24]	56	RCT, blinded	6 months	Agaricus silvaticus fungus extract	Oral	Postsurgical patients with colorectal cancer and pain	Brazil	Integrity of double-blinding unclear
Pawar et al. [27]	27	RCT, blinded	50 days	SAMITAL (three botanical extracts)	Oral solution	Pain from oral mucositis in patients treated for neck/head cancer	India	Control versus exposure group inequity
Pommier et al. [25]	254	RCT, open label	6 weeks	Calendula (plant)	Ointment	Pain after radiotherapy for breast carcinoma	France	Integrity of blinding questionable
Tröger et al. [26]	220	RCT, open label	12 months	Mistletoe	S/C injections	Pancreatic cancer	Serbia	Not blinded
Total	827