Endogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic Derivatives

Figure 2

Enzymatic generation of electrophilic ketoderivatives of EPA (a), DHA (b), and DPA (c). Cox-2, cyclooxygenase-2; PGDS, prostaglandin D synthase; 5-LO, 5-lipoxygenase; 5-HEDH, 5-hydroxyeicosanoid dehydrogenase; deH, cellular dehydrogenases.

(a)

(b)

(c)