Neuroprotective Effects of Clostridium butyricum against Vascular Dementia in Mice via Metabolic Butyrate

Figure 5

Western blot analysis. (a) Western blot of the expression levels of BDNF, p-Akt, Akt, Bcl-2, and Bax in mouse hippocampus. (b) A quantitative analysis of the protein levels of BDNF from each group normalized to the loading control β-actin (c). (d) Bar graphs showing the protein level ratios of p-Akt/Akt and Bcl-2/Bax from each group; Sham, sham-operated group; VaD, VaD model group; H, C. butyricum- (1 × 10⁸ CFU-) treated group; M, C. butyricum- (1 × 10⁷ CFU-) treated group; and L, C. butyricum- (1 × 10⁶ CFU-) treated group. Error bars indicate SD; for each group. and versus sham group; and versus VaD group.

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