Review Article
Biology of Ageing and Role of Dietary Antioxidants
Table 1
Selected longevity determined genes recently recognized in fruit flies, for which allelic variation is associated with extension in longevity.
| Gene names | Molecular mechanism |
| Mth | A P-element insertion at Mth increases lifespan by 35% [31] | Indy | P-element insertion at Indy shows extended mean lifespan [35] | Chico | Heterozygous for chico shows an increase in median lifespan [36] | dTOR | Inhibition of TOR pathway leads to 24–26% lifespan extension [37] | Sirtuins | Gene upregulation of sirtuins increases the lifespan [38] |
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