Impact of Immunogenetic IL28B Polymorphism on Natural Outcome of HCV Infection
Table 2
IL28B rs12979860 variant frequencies in blood donors and patients with HCV infection and different outcomes. Caucasian individuals reported in literature (PubMed), 2009–2013.
Blood donors (HCV neg.)
Spontaneous clearance of HCV
HCV patients
HCV patients total
Chronic HCV
Mild/moderate fibrosis
Cirrhosis
Hepatocellular carcinoma
Mixed cryoglobulinemia S.
Number (%)
Number (%)
Number (%)
Number (%)
Number (%)
Number (%)
Number (%)
Number (%)
IL28B genotype
CC
631 (46.2)
273 (68.8)
1004 (39.6)
212 (31.9)
126 (31.6)
6 (17.1)
99 (39.6)
1447 (37.3)
CT
599 (43.8)
102 (25.7)
1225 (48.3)
373 (56.2)
204 (51.1)
21 (60.0)
113 (45.2)
1936 (49.9)
TT
136 (10.0)
22 (5.5)
305 (12.0)
79 (11.9)
69 (17.3)
8 (22.8)
38 (15.2)
499 (12.8)
Total
1366 (100.0)
397 (100.0)
2534 (100.0)
664 (100.0)
399 (100.0)
35 (100.0)
250 (100.0)
3882 (100.0)
( value)a
—
Ref.
118.8 (<0.001)
135.9 (<0.001)
112.4 (<0.001)
40.5 (<0.001)
55.7 (<0.001)
148.9 (<0.001)
IL28B dominant model
CC
631 (46.2)
273 (68.8)
1004 (39.6)
212 (31.9)
126 (31.6)
6 (17.1)
99 (39.6)
1447 (37.3)
CT + TT
735 (53.8)
124 (31.2)
1530 (60.4)
452 (68.1)
273 (68.4)
29 (82.9)
151 (60.1)
2435 (62.7)
Total
1366 (100.0)
397 (100.0)
2534 (100.0)
664 (100.0)
399 (100.0)
35 (100.0)
250 (100.0)
3882 (100.0)
( value)a
—
Ref.
118.6 (<0.001)
135.9 (<0.001)
110.1 (<0.001)
37.5 (<0.001)
53.4 (<0.001)
148.6 (<0.001)
IL28B allele
C
1861 (68.1)
648 (81.6)
3233 (63.8)
797 (60.0)
456 (57.1)
33 (47.1)
311 (62.2)
4830 (62.2)
T
871 (31.9)
146 (18.4)
1835 (36.2)
531 (40.0)
342 (42.9)
37 (52.9)
189 (37.8)
2934 (37.8)
Total
2732 (100.0)
794 (100.0)
5068 (100.0)
1328 (100.0)
798 (100.0)
70 (100.0)
500 (100.0)
7764 (100.0)
( value)a
—
Ref.
97.4 (<0.001)
106.7 (<0.001)
112.1 (<0.001)
45.8 (<0.001)
60.3 (<0.001)
117.7 (<0.001)
Pearson’s chi-square with spontaneous clearance of HCV as reference group.