|
Growth factor | Function |
|
EGF | Cellular proliferation |
Differentiation of epithelial cells |
|
FGF | Stimulates angiogenesis |
Cellular migration |
Stimulates the proliferation of capillary endothelial cells |
Production of granulation tissue |
|
HGF | Stimulation of hepatocyte proliferation and liver tissue regeneration |
Stimulates angiogenesis |
Mitogen for endothelial cells |
Antifibrotic |
|
IGF-1 | Proliferation of myoblasts and fibroblasts |
Stimulation of protein synthesis |
Mediator in growth and repair of skeletal muscle |
Enhances bone formation by proliferation and differentiation of osteoblasts |
Enhances collagen and matrix synthesis |
|
PDAF | Induces vascularization by stimulating vascular endothelial cells |
|
PDEGF | Stimulates the proliferation of keratinocytes and dermal fibroblasts |
|
PDGF | Macrophage activation |
Stimulates angiogenesis |
Fibroblast chemotaxis and proliferative activity |
Attracts stem cells and white blood cells |
Enhances collagen synthesis |
Contributes to tissue remodeling |
Enhances the proliferation of bone cells |
|
TGF- | Enhances the proliferative activity of fibroblasts |
Stimulates biosynthesis of type 1 collagen and fibronectin |
Induces deposition of bone matrix |
Inhibits osteoclast formation and bone resorption |
Regulation in balance between fibrosis and myocyte regeneration |
Control of angiogenesis and fibrosis |
Immunosuppressant during inflammatory phase |
|
VEGF | Stimulates angiogenesis |
Migration and mitosis of endothelial cells |
Creation of blood vessel lumen |
Chemotactic for macrophages and granulocytes |
Vasodilation |
|