Dipeptidyl Peptidase 10 (DPP10₇₈₉): A Voltage Gated Potassium Channel Associated Protein Is Abnormally Expressed in Alzheimer’s and Other Neurodegenerative Diseases

Figure 5

DPP10₇₈₉ and tau colocalization in AD. Immunohistochemical colocalization of DPP10₇₈₉ with phosphorylated tau (p-tau) in tangles and plaque-associated dystrophic neurites. DPP10₇₈₉ (green) partially or fully colocalized with p-tau (red) in tangles (a, b, e, and g) and in plaque-associated dystrophic neurites (c, d). DPP10₇₈₉ was also present in intracellular vesicle-like structures (f) where very weak staining for p-tau was present. DPP10₇₈₉ immunoreactivity was also found in some tangles in the entorhinal region which were devoid of p-tau staining (h). DPP10₇₈₉ (green) did not colocalize with amyloid-β plaques (red) in AD brain (i). Scale bar is 10 μm. (a) and (c) used Tau2 ab and the remaining images are with AT8 ab.

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