Unexpected Lack of Deleterious Effects of Uranium on Physiological Systems following a Chronic Oral Intake in Adult Rat
Figure 7
Effects of uranium on enzymes of xenobiotic metabolism in the liver. The molecules of phases I, II, and III of xenobiotic metabolism were measured in control animals (NC: noncontaminated) and in animals contaminated by uranium (U) in their drinking water at various concentrations (10, 40, or 120 mg/L). Gene expression: the mRNA levels are expressed as a ratio to the reference gene HPRT (hypoxanthine-guanine phophoribosyltransferase, a housekeeping gene). Data are mean ± SEM of 8 animals. Protein expression: protein levels are expressed as a ratio to the reference gene GAPDH (glyceraldehyde 3-phosphate dehydrogenase, a housekeeping gene). Data are mean ± SD of 8 animals. CYP activities: enzyme activities are expressed in picomoles per minute per whole liver and values are normalized to the noncontaminated group. Data are mean ± SD of 6 animals. *: significantly different from control values. **: significantly different from control values.
