Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes

Table 2

The serum biomarker levels in Sod1^−/− mice.

Markers	Concentrations	Sod1^+/+	Sod1^−/−	value
IL-10	ng/mL	425 ± 54	451 ± 60	0.495
IL-11	pg/mL	39 ± 14.4	33 ± 13.2	0.627
IL-12p70	ng/mL	ND	ND	—
IL-17	pg/mL	ND	ND	—
IL-18	ng/mL	10 ± 1.1	12 ± 1.21	0.105
IL-1alpha	pg/mL	83 ± 63	134 ± 89.4	0.467
IL-1beta	ng/mL	12 ± 1.1	13 ± 1.6	0.268
IL-2	pg/mL	ND	ND	—
IL-3	pg/mL	ND	ND	—
IL-4	pg/mL	20.2 ± 0.0	20.2 ± 0.0	1
IL-5	ng/mL	0.23 ± 0.066	0.19 ± 0.055	0.406
IL-6	pg/mL	4.4 ± 1.7	18 ± 14.3	0.102
IL-7	ng/mL	0.02 ± 0.016	0.05 ± 0.025	0.296
IP-10	pg/mL	99 ± 17.1	150 ± 60.3	0.109
M-CSF	pg/mL	6.9 ± 0.50	6.0 ± 0.25	0.010*
MCP-1	pg/mL	100 ± 34.2	124 ± 60.0	0.457
MCP-3	pg/mL	235 ± 50.9	235 ± 69.3	0.996
MCP-5	pg/mL	18 ± 1.7	24 ± 7.0	0.094
MIP-1alpha	ng/mL	1.6 ± 0.21	1.7 ± 0.09	0.307
MIP-1beta	pg/mL	55 ± 16.5	80 ± 17.5	0.005*
MIP-1gamma	pg/mL	26 ± 3.6	34 ± 3.7	0.013*
MIP-2	pg/mL	18 ± 2.1	20 ± 5.2	0.371
MIP-3beta	ng/mL	1.8 ± 0.37	1.7 ± 0.14	0.349
MDC	pg/mL	547 ± 234	626 ± 42	0.481
RANTES	pg/mL	0.26 ± 0.130	0.45 ± 0.049	0.014*
TNF-alpha	ng/mL	0.066 ± 0.004	0.077 ± 0.010	0.041*
TPO	ng/mL	75 ± 9.4	86.5 ± 5.6	0.049*

ND indicates “not detected”. indicates a significant difference.