Review Article
Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes
Table 1
The age-related pathologies in Sod1−/− mice.
| Brain | Acceleration of Alzheimer’s disease | [11, 12] | Eye | Macular degeneration | [13, 14] | | Cataract | [15] | | Dry eye | [16, 17] | Ear | Cochlear hair cell loss | [18] | | Hearing loss | [19] | Blood | Hemolytic anemia | [20] | Bone | Osteopenia | [21, 22] | Skin | Skin atrophy | [23, 24] | Muscle | Skeletal muscle atrophy | [25] | Pancreas | Glucose intolerance | [26, 27] | Liver | Hepatocellular carcinoma | [9] | | Fatty deposits | [28] | Ovary | Infertility | [29, 30] | | Luteal degeneration | [31] |
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