Circuit Models and Experimental Noise Measurements of Micropipette Amplifiers for Extracellular Neural Recordings from Live Animals
Figure 2
(a) Circuit diagram of the micropipette neural amplifier deigned for in vivo single-cell extracellular neural recordings of conscious rodents using a sharp-tipped glass micropipette. ( = 1.5 nF, = 0.1 μF, = 1 GΩ, = 20 KΩ, = 27 KΩ, = 10 KΩ, = 1 KΩ, and = 200 KΩ) (b) Schematic diagram illustrating the experimental setup used to measure the intrinsic input-referred noise of the neural amplifier. (c) Schematic diagram of measuring the input capacitance of the neural amplifier. (d) Experimental setup to characterize the overall noise of the neural amplifier with the glass micropipette (light off) and the environmental noise (light on) generated by a 60 Hz power-line attached to a light bulb using dead gerbil brain tissue submerged in normal saline.
