Biological Activities of Phosphocitrate: A Potential Meniscal Protective Agent
PC inhibited the proliferation of OA meniscal cells. OA meniscal cells and human foreskin fibroblast were plated in six-well cluster plates and cultured in the presence or absence of PC. (a) There were about 55% fewer OA meniscal cells in the PC-treated (1 mM PC) wells than that in the untreated wells (the right bar group; ). In contract, PC had no effect on the proliferation of human foreskin fibroblast (the left group bars). (b) PC and EHDP inhibited the proliferation of OA meniscal cells in a dose-dependent manner.
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