Highlights from the Functional Single Nucleotide Polymorphisms Associated with Human Muscle Size and Strength or FAMuSS Study

Table 2

FAMuSS findings: genetic loci tested for association with body composition at baseline and in response to resistance training and cardiometabolic biomarkers at baseline*.

Gene	Name	Reference
AKT1	V-akt murine thymoma viral oncogene homolog 1	[39]
ANGPT3	Angiopoietin-like 3	[40]
BCL7B	B-cell CLL/lymphoma 7B	[40]
BMP2	Bone morphogenetic protein 2	[40]
CDKAL1	CDK5 regulatory subunit associated protein 1-like 1	[40]
CDKN2A/2B	Cyclin-dependent kinase inhibitor 2A and 2B	[40]
CDKN2BAS/CDNKN2B-AS1 (ANRIL)	CDKN2B-AS1 CDKN2B antisense RNA 1	[40]
CILP2	Cartilage intermediate layer protein 2	[40]
FTO	Fat mass and obesity associated	[42]
GALNT2	UDP-N-acetyl-alpha-D-galactosame:polypeptide N-acetylgalactosaminyltransferase 2	[40]
GNPDA2	Glucosamine-6-phosphate deaminase 2	[42]
HHEX	Hematopoietically expressed homeobox	[40]
HNF1A	HNF1 homeobox A	[40]
IGFBP2	Insulin-like growth factor binding protein 2	[40]
IL15	Interleukin 15	[23]
IL15Rα	Interleukin 15 receptor, alpha	[23]
INSIG2	Insulin-induced gene 2	[41]
KCTD10	Potassium channel tetramerisation domain containing 10	[40]
KCTD15	Potassium channel tetramerisation domain containing 15	[42]
KCNJ11	Potassium inwardly rectifying channel, subfamily J, member 11	[40]
MC4R	Melanocortin-4 receptor	[42]
MRAS	Muscle RAS oncogene homolog	[40]
MTCH2	Mitochondrial carrier 2	[42]
NEGR1	Neuronal growth regulator 1	[42]
PPARα	Peroxisome proliferator-activated receptor alpha	[43]
PPARG2	Peroxisome proliferator-activated receptor gama	[40]
RETN	Resistin	[22]
SH2B1	SH2B adaptor protein 1	[42]
SLC30A8	Solute carrier family 30, member 8	[40]
SORT1	Sortilin 1	[40]
TCF7L2	Transcription factor 7-like 2	[40]
TMEM18	Transmembrane protein 18	[42]
TRIB1	Tribbles pseudokinase 1	[40]

∗Bolded genes were significantly associated with the phenotypes of interest.