Pharmacodynamic Analysis of Magnetic Resonance Imaging-Monitored Focused Ultrasound-Induced Blood-Brain Barrier Opening for Drug Delivery to Brain Tumors

Figure 5

(a)–(c) R₁ change as a function of time before and after FUS exposure for normal animals, 10-day and 17-day tumor animals. (d–f) The corresponding R₁ accumulation as a function of time over 80 minutes for (a)–(c).

(a)

(b)

(c)

(d)

(e)

(f)