Triterpenes and the Antimycobacterial Activity of Duroia macrophylla Huber (Rubiaceae)
Table 3
Minimum inhibitory concentration (MIC) of dichloromethane fractions from the leaves of D. macrophylla (1st collection) against M. tuberculosis strains.
Fraction
M. tuberculosis
H37Rv (g/mL)
INHr (g/mL)
RMPr (g/mL)
Fr 1–4
R
>200
R
>200
R
>200
Fr 1–4.17–20
R
>200
R
>200
R
>200
Fr 5
R
>200
R
>200
R
>200
Fr 6–12
S
50
S
100
S
100
Fr 6–12.30
R
>200
R
>200
R
>200
Fr 6–12.33–35
R
>200
R
>200
R
>200
Fr 6–12.38–63
R
>200
R
>200
R
>200
Fr14–16
S
100
S
50
S
100
Fr 17–21
R
>200
R
>200
R
>200
Fr 17.21.1–5
R
>200
R
>200
R
>200
Fr 25–40
S
200
S
200
S
200
Fr 25–40.2
R
>200
S
200
S
200
Fr 25–40.6
S
200
S
200
S
200
Fr 25–40.6.32
S
100
S
100
S
100
Fr 41–44
S
100
S
50
S
100
Fr 46–56
S
200
S
200
S
100
Fr 46–56.5
S
200
S
200
S
200
Fr 46–56.8–10
S
50
S
50
S
50
Fr 46–56.13–17
R
>200
R
>200
R
>200
Fr 57
S
100
S
200
S
200
Fr 57.6–12
S
100
R
>200
R
>200
Fr 63–65
S
100
S
25
S
100
Fr 66–68
S
200
S
100
S
200
Fr 70–74
R
>200
S
200
R
>200
Fr 76–86
R
>200
S
200
S
200
Fr 87–92
S
200
S
50
S
100
Fr 94–99
S
200
S
200
S
100
Fr: fraction, R: resistant, S: sensible, H37Rv: sensible strain, INHr: isoniazid resistant strain, RMPr: rifampicin resistant strain. Fractions with MIC > 200 g/mL were considered inactive.
