Research Article

Lovastatin in Aspergillus terreus: Fermented Rice Straw Extracts Interferes with Methane Production and Gene Expression in Methanobrevibacter smithii

Figure 1

Biosynthesis pathway of cholesterol production in humans (solid-line markers) and phospholipids production in Archaea (dotted-line markers). HMG-CoA reductase is the common enzyme converting HMG-CoA to mevalonic acid in the two pathways. Lovastatin is an inhibitor of HMG-CoA reductase and thus reduces the production of mevalonic acid in both pathways (modified from http://ourbiochemistry.blogspot.com/2008/08/29-cholesterol-synthesis.html).
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