The Influence of Micronutrients in Cell Culture: A Reflection on Viability and Genomic Stability

Table 5

Overview of the data addressed in this review.

Micronutrient	Evidence of genomic instability induction		Concentration in common cell-culture media versus physiological concentration	Optimal concentration proposed for cell culture
	Deficiency	Excess
Vitamin A	+	+	Lower	Studied
Vitamin B7	+	+	Higher	Requires more studies
Vitamin B9	+	+	Higher	Studied
Vitamin B12	+	NA	Higher	Studied
Vitamin C	+	+	Unknown	Studied
Vitamin E	−	+	Unknown	Studied
Copper	+	+	Lower	Studied
Iron	+	+	Lower	Studied
Magnesium	NA	+	Similar	Studied
Selenium	+	−	Lower	Studied
Zinc	+	+	Lower	Studied

NA: Not available.
(−) Negative: the available data indicate no effect.
(+) Positive: the available data indicate an effect.