Production of Adenosine by Ectonucleotidases: A Key Factor in Tumor Immunoescape
Figure 1
Effects of adenosine produced by CD39+/CD73+ cells on target cells. Cancer cells, Tregs, Th17, and MDSCs could produce adenosine through degradation of ATP/ADP by CD39 and CD73. Then adenosine binds on target cells, such as immune cells, cancer cells, or endothelial cells and modifies their activity.