Review Article
The Emerging Role of PEDF in Stem Cell Biology
Table 1
Effects of PEDF on different types of stem cells.
| Stem cell type | PEDF effect | Reference |
| Human embryonic stem cell | Proliferation, support, and survival | [22, 23] |
| Neural stem cell | Self-renewal |
[31ā33] | Maintenance of multipotency | Activation of cell division | Antiapoptotic effects |
| Retinal stem cell | Self-renewal |
[35, 37, 38] | Cell expansion | Inhibits migration of and induces apoptosis of endothelial cells | Regression of CNV (at low doses) | Development of neovascularisation (at high doses) |
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