Molecular Imaging, Pharmacokinetics, and Dosimetry of ¹¹¹In-AMBA in Human Prostate Tumor-Bearing Mice

Table 2

Pharmacokinetic parameters of plasma in PC-3 tumor-bearing mice after intravenous injection of 10 μCi/mouse ¹¹¹In-AMBA (mean ± SEM, 𝑛=5).

Parameter	Unit	Value
A	% ID/g	6.15±0.69
B	% ID/g	1.43±0.61
α	1/h	1.19±0.85
β	1/h	0.03±0.01
AUC0−168h	h × (% ID/g)	66.4±17.3
𝑡1/2𝛼	h	1.53±0.69
𝑡1/2𝛽	h	30.7±8.56
𝐶max	% ID/g	7.37±0.64

A, B, α, β: macro rate constants; 𝑡_1/2𝛼, 𝑡_1/2𝛽: distribution and elimination half-lives; AUC_0−168h: area under concentration of ¹¹¹In-AMBA versus time curve; 𝐶_max: maximum concentration in plasma.