Mechanism of Catch Force: Tethering of Thick and Thin Filaments by Twitchin

<table>Thick filament from ABRM with immunogold labeling of the kinase domain of twitchin. Gold particles are 10 nm in diameter. Filaments were stained with 2% uranyl acetate. Striated appearance of filaments has a <svg height="5.7874999" id="M60" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.825 5.7874999" width="10.825" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,5.7875)">
<g transform="translate(72,-67.37)">
<text transform="matrix(1,0,0,-1,-71.95,67.42)">
<tspan style="font-size: 12.50px; " x="0" y="0">∼</tspan>
</text>
</g>
</g>
</svg>14 nm repeat and there is about 200 nm between clusters of gold particles.</table>

BioMed Research International

fig11

Figure 11

Figure 11: Mechanism of Catch Force: Tethering of Thick and Thin Filaments by Twitchin 