Mathematical Modeling: Bridging the Gap between Concept and Realization in Synthetic Biology
Figure 10
Model predictions and analysis of the repressor-activator system in Guido et al. [8]. (a) Simulations with baseline deterministic model: dependence of the model response (GFP fluorescence) of the repressor-activator system on arabinose concentration, with IPTG concentration maintained constant. The model simulation is shown with a blue line and experimental data points are shown with red circles. (b) Simulations with the extended stochastic model: distribution of GFP fluorescence within the cell population for levels of arabinose ranging from no arabinose (solid lines toward left) to the maximum possible level of arabinose (dashed lines toward right); IPTG concentration is maintained constant throughout. Stochastic model simulations are shown with blue lines and experimental data is shown with red lines (from Guido et al. [8], with permission).
