OXavidin for Tissue Targeting Biotinylated Therapeutics

Figure 3

Oxidized avidin in vivo residence and biotin uptake. Diffusion kinetic of ¹²⁵I-labeled avidin and oxidized avidin injected in a limb of Balb/c mice (a)–(d) and uptake of intravenously administered ¹¹¹In-ST2210 (e)–(h), after 1, 24, or 48 hours. Mice were sacrificed 1 hour after ¹¹¹In-ST2210 injection and injected sites as well as samples of non target organs were weighted and counted in a gamma-counter. Each point is the average of 5 mice. Bars represent standard deviation. Student’s 𝑡 test was used for statistical analysis. NS: Not significant.