IL-18 Does not Increase Allergic Airway Disease in  Mice When Produced by BCG

Amniai, L.; Biet, F.; Marquillies, P.; Locht, C.; Pestel, J.; Tonnel, A.-B.; Duez, C.

doi:https://doi.org/10.1155/2007/67276

BioMed Research International

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Research Article | Open Access

Volume 2007 | Article ID 067276 | https://doi.org/10.1155/2007/67276

IL-18 Does not Increase Allergic Airway Disease in Mice When Produced by BCG

L. Amniai,^1,2,3F. Biet,⁴P. Marquillies,^1,2,3C. Locht,^2,5J. Pestel,^6,7A.-B. Tonnel,^1,2,3and C. Duez^1,2,3

Academic Editor: Shahid Jameel

Received24 Jul 2007

Revised10 Oct 2007

Accepted19 Nov 2007

Published27 Jan 2008

Abstract

Whilst BCG inhibits allergic airway responses in murine models, IL-18 has adversary effects depending on its environment. We therefore constructed a BCG strain producing murine IL-18 (BCG-IL-18) and evaluated its efficiency to prevent an asthma-like reaction in mice. BALB/cByJ mice were sensitized (day (D) 1 and D10) by intraperitoneal injection of ovalbumin (OVA)-alum and primary (D2022) and secondary (D62, 63) challenged with OVA aerosols. BCG or BCG-IL-18 were intraperitonealy administered 1 hour before each immunization (D1 and D10). BCG-IL-18 and BCG were shown to similarly inhibit the development of AHR, mucus production, eosinophil influx, and local Th2 cytokine production in BAL, both after the primary and secondary challenge. These data show that IL-18 did not increase allergic airway responses in the context of the mycobacterial infection, and suggest that BCG-IL-18 and BCG are able to prevent the development of local Th2 responses and therefore inhibit allergen-induced airway responses even after restimulation.

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Copyright © 2007 L. Amniai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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