Review Article
Ulcerative Lesions in Behcet's Disease
Table 2
Therapy of types/condition and Floor Chart of 1st, 2nd, 3rd line medicine.
(a) Topical treatments of ulcerations |
| Treatment | Dose | Used as first-line therapy | Used as alternative therapy |
| Topical steroids | 3 times a day topically | Oral and genital ulcers | | %5 Amlexanox paste | 4/day topically | Oral ulcers | | Sucralfate suspension | 4/day topically for 3 months | Orogenital ulcers | | Triamcinolone acetonide 40 mg ampule | Intralesionally 5 mg/mL | Severe orogenital ulcers | | Lidocaine %2–5 | 4/day topically as mouthwashes, before meals | Severe and multiple oral ulcers in Behçet’s patients with insufficients oral intake by pain, | | Chlorhexidine gluconate rinses %1-2 | Topically as mouthwashes | Oral ulcers | | Tetracycline | 250 mg in 5 mL water solution, held in mouth for 2 min once a day | | Oral ulcers | rhGM-CSF 300 μg ampule | Intralesionally injection in every 2 weeks | | Large genital ulcers |
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(b) Systemic treatments |
| Treatment | Dose | Used as first-line therapy | Used as alternative therapy |
| Systemic steroids | 5–100 mg/day orally | | Orogenital and gastrointestinal ulcerations | Colchicine | 0.5–1.5 mg/day orally | Oral and genital ulcers | | Thalidomide | 100–300 mg/day orally | | Orogenital ulcers | Dapsone | 100 mg/day orally | | Oral and genital ulcers | Pentoxifylline | 300 mg/day orally | | Orogenital and leg ulcers | Levamisole | 150 mg in 3 doses/day every 2 day 1 week | | Mucocutaneous ulcers | Penicilline | U/3 week | | Mucocutaneous ulcers | Azithromycin | 500 mg 3 times a week for 4weeks | | Mucocutaneous ulcers | Interferon-α | 5 million U/day im or s.c. | | Mucocutaneous ulcers | Sulfasalazine | 1–3 gr/day orally | Gastrointestinal ulcers | | Surgery | | | Gastrointestinal ulcers |
| Combination therapies | | | | Penicilline + colchicine | Penicilline U/3 week, colchicine 1.5 mg/day | | Mucocutaneous ulcers |
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