Palatable Levocetirizine Dihydrochloride Solid Dispersed Fast-Dissolving Films: Formulation and In Vitro and In Vivo Characterization

Table 3

Score mean for evaluation of palatability and in vivo disintegration time on human participants of the selected fast-dissolving films of levocetirizine dihydrochloride.

Formulation code	V-1	V-2	V-3	V-4	V-5	V-6	Score mean	In vivo disintegration time (sec.)
	Score
Drug powder	4	4	4	4	4	4	4.0	—
LF-4	2	3	2	4	2	4	2.8	8.14 ± 3.38
LF-5	0	2	1	1	3	1	1.3	—
LF-6	0	2	1	1	2	0	1.0	—
LF-7	0	1	0	0	1	0	0.3	9.43 ± 2.16

(n = 3; mean ± SD), V: volunteer, scores: 0-non bitter, 1-slightly bitter, 2-bitter, 3-moderate bitter, and 4-strong bitter (, ).