Palatable Levocetirizine Dihydrochloride Solid Dispersed Fast-Dissolving Films: Formulation and In Vitro and In Vivo Characterization

Table 2

Evaluation parameters of the prepared fast-dissolving films of levocetirizine dihydrochloride (LF1-1-LF-7).

Evaluation parameter	Formulation code
	LF-1	LF-2	LF-3	LF-4	LF-5	LF-6	LF7
Appearance	Transparent	Transparent	Transparent	Transparent	Opaque	Opaque	Opaque
Weight variation (mg)	21.77	23.81	24.21	25.91	28.43	29.02	30.29
	±1.81	±2.20	±2.80	±2.60	±2.51	±3.01	±2.01
Thickness (μm)	20.78	23.22	23.89	23.56	24.44	25.63	27.46
	±1.80	±1.73	±1.96	±2.28	±1.58	±1.69	±1.09
Folding endurance	>300	>300	>300	>300	>300	>300	>300
Surface pH	5.80	5.96	5.69	5.84	5.94	5.91	5.85
	±0.11	±0.12	±0.18	±0.20	±0.10	±0.15	±0.15
Drug content uniformity (%)	99.72	97.67	102.68 ± 1.31	96.06	99.73	98.21	98.31
	±2.70	±1.23		±1.40	±1.20	±0.8	±1.02
Moisture uptake (%)	5.71	6.76	5.33	5.11	6.20	6.62	6.88
	±0.06	±0.16	±0.15	±0.13	±0.09	±0.10	±0.10
Moisture loss (%)	5.88	6.54	6.90	4.17	5.77	5.38	5.20
	±0.071	±0.12	±0.14	±0.07	±0.11	±0.13	±0.12
In vitro disintegration (Sec.)	54	47	40	30	35	28	25
	±2.00	±1.50	±2.50	±3.00	±1.5	±2.5	±2.00
In vitro drug released (%) after one min.	50.29	46.49	55.71	86.82	80.4	83.52	99.22
	±2.97	±3.47	±3.05	±2.20	±3.30	±3.40	±2.20

(n = 3; mean ± SD).